Colts center Jeff Saturday suffered a knee injury during the team’s preseason game Sunday, and although no definitive word has come out about the extent of the injury, Saturday’s coach, quarterback and agent are all talking like he could miss significant time.

“It could be the type of thing where he could be back next week or it could be something major if he needs surgery, and we don’t know right now,” Colts coach Tony Dungy said, per the Indianapolis Star.

Quarterback Peyton Manning has played with Saturday  for 126 regular-season games, the second-most starts by a quarterback and center in the NFL since 1970. Manning was finally back at practice Tuesday as he recovers from his own injury, but he still hasn’t had the comfortable feel of his hands under Saturday’s butt this summer. He didn’t sound optimistic that he would any time soon, either.

“Certainly my prayers are with Jeff and you have your fingers crossed,” Manning said. “It’s pretty well-documented how I feel about him, how the team feels about him and how important he is to this team and this offense.”

Saying “my prayers are with Jeff” doesn’t exactly make it sound like Manning thinks Saturday’s injury is minor.

Saturday’s agent, Ralph Cindrich, said Saturday will seek a second opinion before deciding whether to have surgery: “Right now, it’s too soon to tell what Jeff’s going to do.”